Asymmetric access to the smallest enolate intermediate via organocatalytic activation of acetic ester.
نویسندگان
چکیده
An NHC-catalyzed activation of acetic esters to afford enolate intermediates is disclosed. The catalytically generated triazolium enolate intermediates serve as two-carbon nucleophiles that undergo highly enantioselective reactions with enones and α,β-unsaturated imines to give α-unsubstituted δ-lactones and lactams, respectively.
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عنوان ژورنال:
- Organic letters
دوره 15 22 شماره
صفحات -
تاریخ انتشار 2013